Kanamycin Sulphate Meiji Dosage/Direction for Use

For parenteral use, Kanamycin Sulphate Meiji is dissolved in Water for Injection. The amount of solvent to be added to 0.5-g (potency), 1-g (potency) or 2-g (potency) vials to obtain the desired concentrations are shown in the following table. The solution is so stable as to retain its potency at room temperature, but it is preferable to use immediately after preparation. (See table.)


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IM Administration: Treatment of Tuberculosis: For adults, usually a daily dose of 2 g (potency) kanamycin is administered by IM injection in 2 equally divided doses (morning and evening) twice a week. Otherwise, 1 g (potency) once daily is administered 3 days a week. Kanamycin Sulphate Meiji should be locally applied when necessary.
Kanamycin sulphate Meiji 0.5-0.75 g (potency) is, however, administered as a single dose to elderly patients (>60 years). The dose should be decreased for children and patients with a very small body weight.
In principle, Kanamycin Sulphate Meiji should be used in combination with other antituberculous drugs.
Other Infections: Usually, a daily dose of 1-2 g (potency) kanamycin is injected IM to adults in 1 or 2 equally divided doses. For children, 30-50 mg (potency)/kg of body weight daily is injected IM in 1 or 2 equally divided doses.
Local application should be conducted when necessary.
The dose may be adjusted according to the age of patients and severity of symptoms.
Local Injection: For lymph node tuberculosis, local injection is effective in combination with IM administration. In this case, 1 g (potency) is dissolved in 6 mL of Water for Injection and about 0.7 mL [100 mg (potency)] of the solutions at a time SC injected into the chin or upper sternocleidomastoid for the injected site.
Inhalation Therapy: It is effective in combination with IM administration. In this case, 1 g (potency) is dissolved in 9.2 mL of water for injection, and 1-3 mL of the solutions is given 1-3 times a day with a nebulizer.
Ear Bath: For stubborn, chronic, purulent otitis media, ear bath is effective in combination with IM administration. In this case, 1 g (potency) is dissolved in 5 mL of Water for Injection and 0.6 mL [100 mg (potency)] of the solutions at a time are given by the usual ear bath.